Drug interactions
Ethacrynic acid + Trazodone
Severity: Moderate
Ethacrynic acid and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics such as ethacrynic acid can cause hyponatremia and volume depletion, and trazodone can cause SIADH-related hyponatremia. Used together, the risk of low sodium may be greater, especially in elderly patients. Volume depletion may also worsen orthostatic hypotension from trazodone.
What this interaction means in plain words
Ethacrynic acid and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Trazodone belongs to Central Nervous System.
Why it happens
Additive effects on sodium balance, with diuretic-induced sodium loss and antidepressant-associated SIADH.
What to do
Check serum sodium at baseline and after starting the combination, particularly in older adults. Counsel on symptoms of hyponatremia and orthostasis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Trazodone?
MediHelp rates the interaction as moderate. Ethacrynic acid and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics such as ethacrynic acid can cause hyponatremia and volume depletion, and trazodone can cause SIADH-related hyponatremia. Used together, the risk of low sodium may be greater, especially in elderly patients. Volume depletion may also worsen orthostatic hypotension from trazodone.
How serious is the interaction between Ethacrynic acid and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and after starting the combination, particularly in older adults. Counsel on symptoms of hyponatremia and orthostasis.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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