Drug interactions
Ethinyl estradiol-drospirenone + Fluconazole
Severity: Minor
Ethinyl estradiol-drospirenone and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can modestly raise ethinyl estradiol exposure through CYP3A4 inhibition. Clinical significance is usually small, particularly with the single doses used for vaginal candidiasis, although estrogen-related adverse effects may occasionally increase.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated metabolism of ethinyl estradiol by fluconazole.
What to do
No change is generally needed. Monitor for estrogenic adverse effects such as nausea, breast tenderness or breakthrough bleeding with prolonged fluconazole courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Fluconazole?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole can modestly raise ethinyl estradiol exposure through CYP3A4 inhibition. Clinical significance is usually small, particularly with the single doses used for vaginal candidiasis, although estrogen-related adverse effects may occasionally increase.
How serious is the interaction between Ethinyl estradiol-drospirenone and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is generally needed. Monitor for estrogenic adverse effects such as nausea, breast tenderness or breakthrough bleeding with prolonged fluconazole courses.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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