Drug interactions
Ethinyl estradiol-drospirenone + Hydrochlorothiazide
Severity: Minor
Ethinyl estradiol-drospirenone and Hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone tends to retain potassium, whereas hydrochlorothiazide promotes potassium loss. The effects partly offset each other, so the net effect on potassium is unpredictable and usually small.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Opposing effects on potassium: aldosterone antagonism by drospirenone versus increased distal renal potassium excretion from the thiazide.
What to do
Check serum potassium and blood pressure after starting the combination in patients with hypertension or renal disease. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethinyl estradiol-drospirenone and Hydrochlorothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Hydrochlorothiazide?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone tends to retain potassium, whereas hydrochlorothiazide promotes potassium loss. The effects partly offset each other, so the net effect on potassium is unpredictable and usually small.
How serious is the interaction between Ethinyl estradiol-drospirenone and Hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and blood pressure after starting the combination in patients with hypertension or renal disease. No routine dose change is needed.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
