Drug interactions
Ethinyl estradiol-drospirenone + Levoketoconazole
Severity: Moderate
Ethinyl estradiol-drospirenone and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a potent CYP3A4 inhibitor, which can increase ethinyl estradiol and drospirenone exposure. Drospirenone-related hyperkalemia and estrogenic adverse effects may become more likely.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Levoketoconazole belongs to Endocrine.
Why it happens
Strong CYP3A4 inhibition reduces the hepatic and intestinal metabolism of ethinyl estradiol and drospirenone.
What to do
Monitor serum potassium during the first weeks and watch for estrogenic adverse effects; consider an alternative contraceptive if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Levoketoconazole?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a potent CYP3A4 inhibitor, which can increase ethinyl estradiol and drospirenone exposure. Drospirenone-related hyperkalemia and estrogenic adverse effects may become more likely.
How serious is the interaction between Ethinyl estradiol-drospirenone and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during the first weeks and watch for estrogenic adverse effects; consider an alternative contraceptive if adverse effects occur.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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