Drug interactions
Ethinyl estradiol-drospirenone + Lixisenatide
Severity: Minor
Ethinyl estradiol-drospirenone and Lixisenatide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lixisenatide slows gastric emptying and may reduce or delay absorption of oral drugs, including oral contraceptives. Reduced contraceptive hormone levels could in theory lower contraceptive reliability. The effect is variable and usually small.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Lixisenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Lixisenatide belongs to Endocrine.
Why it happens
Delayed gastric emptying from GLP-1 receptor agonism alters absorption of oral medications.
What to do
Take the oral contraceptive at least 1 hour before lixisenatide injection, or at least 11 hours after it. Consider added barrier contraception if vomiting or diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Lixisenatide
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Lixisenatide?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Lixisenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lixisenatide slows gastric emptying and may reduce or delay absorption of oral drugs, including oral contraceptives. Reduced contraceptive hormone levels could in theory lower contraceptive reliability. The effect is variable and usually small.
How serious is the interaction between Ethinyl estradiol-drospirenone and Lixisenatide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take the oral contraceptive at least 1 hour before lixisenatide injection, or at least 11 hours after it. Consider added barrier contraception if vomiting or diarrhea occurs.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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