Drug interactions
Ethinyl estradiol-drospirenone + Oteseconazole
Severity: Minor
Ethinyl estradiol-drospirenone and Oteseconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oteseconazole inhibits BCRP and may raise exposure to BCRP substrates, including ethinyl estradiol. Oteseconazole is mainly used in women who cannot become pregnant, and its clinical effect on this contraceptive is uncertain.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Oteseconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Oteseconazole belongs to Anti Fungals.
Why it happens
BCRP inhibition by oteseconazole may increase systemic exposure to ethinyl estradiol.
What to do
No routine adjustment is needed. Monitor for estrogenic adverse effects if the combination is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Oteseconazole
- Atorvastatin + Oteseconazole Moderate
- Fluvastatin + Oteseconazole Moderate
- Glibenclamide + Oteseconazole Moderate
- Glyburide-metformin + Oteseconazole Moderate
- Irinotecan + Oteseconazole Moderate
- Lapatinib + Oteseconazole Moderate
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Oteseconazole?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Oteseconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oteseconazole inhibits BCRP and may raise exposure to BCRP substrates, including ethinyl estradiol. Oteseconazole is mainly used in women who cannot become pregnant, and its clinical effect on this contraceptive is uncertain.
How serious is the interaction between Ethinyl estradiol-drospirenone and Oteseconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for estrogenic adverse effects if the combination is used.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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