Drug interactions
Ethinyl estradiol-drospirenone + Paromomycin
Severity: Minor
Ethinyl estradiol-drospirenone and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin acts in the gut and may alter intestinal flora, which was theorised to lower estrogen reabsorption. Evidence of real contraceptive failure is lacking.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Paromomycin belongs to Anti Bacterial.
Why it happens
Proposed reduction of enterohepatic estrogen recycling through gut flora changes; not established clinically.
What to do
No routine change is needed. Counsel on backup contraception if vomiting, diarrhea or missed pills occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Paromomycin?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral paromomycin acts in the gut and may alter intestinal flora, which was theorised to lower estrogen reabsorption. Evidence of real contraceptive failure is lacking.
How serious is the interaction between Ethinyl estradiol-drospirenone and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Counsel on backup contraception if vomiting, diarrhea or missed pills occur.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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