Drug interactions
Ethinyl estradiol-drospirenone + Repotrectinib
Severity: Major
Ethinyl estradiol-drospirenone and Repotrectinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib induces CYP3A4 and can reduce contraceptive hormone exposure enough to compromise efficacy. Repotrectinib may harm a fetus, so contraceptive failure is particularly important.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ethinyl estradiol-drospirenone belongs to Endocrine; Repotrectinib belongs to Oncology.
Why it happens
CYP3A4 induction by repotrectinib increases metabolism of ethinyl estradiol and drospirenone.
What to do
Advise an effective nonhormonal contraceptive during treatment and for the period stated in labeling after the last dose. Do not rely on hormonal contraceptives alone.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Repotrectinib?
MediHelp rates the interaction as major. Ethinyl estradiol-drospirenone and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Repotrectinib induces CYP3A4 and can reduce contraceptive hormone exposure enough to compromise efficacy. Repotrectinib may harm a fetus, so contraceptive failure is particularly important.
How serious is the interaction between Ethinyl estradiol-drospirenone and Repotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an effective nonhormonal contraceptive during treatment and for the period stated in labeling after the last dose. Do not rely on hormonal contraceptives alone.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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