Drug interactions
Ethinyl estradiol-drospirenone + Rucaparib
Severity: Minor
Ethinyl estradiol-drospirenone and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate inhibitor of CYP3A4 among other enzymes, and may raise exposure to ethinyl estradiol and drospirenone. The increase is expected to be modest. Patients on rucaparib are generally advised against pregnancy and need reliable contraception.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Rucaparib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by rucaparib reduces metabolism of ethinyl estradiol and drospirenone.
What to do
No dose change is usually needed. Monitor for estrogenic or potassium-related effects, and note that hormonal contraceptives may need a supplementary barrier method during PARP inhibitor therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethinyl estradiol-drospirenone and Rucaparib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Rucaparib?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a moderate inhibitor of CYP3A4 among other enzymes, and may raise exposure to ethinyl estradiol and drospirenone. The increase is expected to be modest. Patients on rucaparib are generally advised against pregnancy and need reliable contraception.
How serious is the interaction between Ethinyl estradiol-drospirenone and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for estrogenic or potassium-related effects, and note that hormonal contraceptives may need a supplementary barrier method during PARP inhibitor therapy.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
