Drug interactions
Ethinyl estradiol-drospirenone + Sotalol
Severity: Minor
Ethinyl estradiol-drospirenone and Sotalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can slightly raise serum potassium, and drospirenone also promotes potassium retention. Sotalol prolongs QT, so any electrolyte disturbance is relevant, although this combination more often poses a hyperkalemia concern of low magnitude.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Sotalol belongs to Cardiovascular.
Why it happens
Mild additive effect: beta-blockade reduces cellular potassium uptake while drospirenone reduces renal excretion.
What to do
Monitor serum potassium and electrolytes as usual during sotalol therapy; no change in dosing is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Sotalol?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Beta-blockers can slightly raise serum potassium, and drospirenone also promotes potassium retention. Sotalol prolongs QT, so any electrolyte disturbance is relevant, although this combination more often poses a hyperkalemia concern of low magnitude.
How serious is the interaction between Ethinyl estradiol-drospirenone and Sotalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and electrolytes as usual during sotalol therapy; no change in dosing is required.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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