Drug interactions
Ethinyl estradiol-drospirenone + Stiripentol
Severity: Moderate
Ethinyl estradiol-drospirenone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces several CYP enzymes, including CYP3A4, so exposure to the contraceptive hormones may change unpredictably. Reduced hormone levels could lower contraceptive reliability. Many patients on stiripentol also take other enzyme-inducing antiseizure drugs.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed inhibition and induction of CYP3A4 and other enzymes by stiripentol alters metabolism of ethinyl estradiol and drospirenone.
What to do
Recommend an additional or alternative non-hormonal contraceptive method. Review the contraceptive plan with the neurologist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Stiripentol?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces several CYP enzymes, including CYP3A4, so exposure to the contraceptive hormones may change unpredictably. Reduced hormone levels could lower contraceptive reliability. Many patients on stiripentol also take other enzyme-inducing antiseizure drugs.
How serious is the interaction between Ethinyl estradiol-drospirenone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Recommend an additional or alternative non-hormonal contraceptive method. Review the contraceptive plan with the neurologist.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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