Drug interactions
Ethinyl estradiol-drospirenone + Trimipramine
Severity: Minor
Ethinyl estradiol-drospirenone and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogen-containing contraceptives may reduce the oxidative metabolism of tricyclic antidepressants, which could raise trimipramine levels. This may increase anticholinergic, sedative and cardiovascular adverse effects, although the evidence is limited and the effect is variable.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Trimipramine belongs to Central Nervous System.
Why it happens
Ethinyl estradiol may inhibit hepatic oxidative metabolism of tricyclic antidepressants, though the mechanism is not firmly established.
What to do
Monitor for sedation, dry mouth, orthostatic hypotension and tachycardia after starting the contraceptive. Reduce the trimipramine dose if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Trimipramine?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogen-containing contraceptives may reduce the oxidative metabolism of tricyclic antidepressants, which could raise trimipramine levels. This may increase anticholinergic, sedative and cardiovascular adverse effects, although the evidence is limited and the effect is variable.
How serious is the interaction between Ethinyl estradiol-drospirenone and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dry mouth, orthostatic hypotension and tachycardia after starting the contraceptive. Reduce the trimipramine dose if adverse effects emerge.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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