Drug interactions
Etomidate + Mirtazapine
Severity: Minor
Etomidate and Mirtazapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is an intravenous anesthetic induction agent, and mirtazapine adds sedative effects. The combination may modestly deepen or prolong sedation or hypotension in the perioperative setting, although the anesthetist titrates etomidate to effect.
What this interaction means in plain words
Etomidate and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etomidate belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation by etomidate and H1 antagonism by mirtazapine.
What to do
Inform the anesthesia team of mirtazapine use and titrate the induction dose to effect. Monitor recovery for prolonged sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Etomidate with Mirtazapine?
MediHelp rates the interaction as minor. Etomidate and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etomidate is an intravenous anesthetic induction agent, and mirtazapine adds sedative effects. The combination may modestly deepen or prolong sedation or hypotension in the perioperative setting, although the anesthetist titrates etomidate to effect.
How serious is the interaction between Etomidate and Mirtazapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of mirtazapine use and titrate the induction dose to effect. Monitor recovery for prolonged sedation.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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