Drug interactions
Etomidate + Trazodone
Severity: Moderate
Etomidate and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is an anesthetic induction agent, and trazodone's sedative and hypotensive properties may add to its depressant effects during anesthesia. The effect is usually manageable in a monitored setting.
What this interaction means in plain words
Etomidate and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etomidate belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression and possible additive hypotension.
What to do
Inform the anesthesia team of trazodone use and titrate anesthetic dose to effect with hemodynamic monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Etomidate with Trazodone?
MediHelp rates the interaction as moderate. Etomidate and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is an anesthetic induction agent, and trazodone's sedative and hypotensive properties may add to its depressant effects during anesthesia. The effect is usually manageable in a monitored setting.
How serious is the interaction between Etomidate and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of trazodone use and titrate anesthetic dose to effect with hemodynamic monitoring.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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