Drug interactions
Etonogestrel + Fluconazole
Severity: Minor
Etonogestrel and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etonogestrel is metabolized by CYP3A4, and fluconazole may raise progestin concentrations. Contraceptive efficacy is not reduced, but progestogenic adverse effects might increase.
What this interaction means in plain words
Etonogestrel and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etonogestrel belongs to Endocrine; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4, reducing etonogestrel metabolism.
What to do
No dose change is generally needed. Counsel the patient to report bleeding changes or progestogenic side effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Etonogestrel
Frequently asked questions
Can I take Etonogestrel with Fluconazole?
MediHelp rates the interaction as minor. Etonogestrel and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etonogestrel is metabolized by CYP3A4, and fluconazole may raise progestin concentrations. Contraceptive efficacy is not reduced, but progestogenic adverse effects might increase.
How serious is the interaction between Etonogestrel and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Counsel the patient to report bleeding changes or progestogenic side effects.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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