Drug interactions
Etonogestrel + Levoketoconazole
Severity: Moderate
Etonogestrel and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and can raise etonogestrel exposure, increasing progestogenic effects. Contraceptive efficacy is not expected to be reduced.
What this interaction means in plain words
Etonogestrel and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etonogestrel belongs to Endocrine; Levoketoconazole belongs to Endocrine.
Why it happens
Strong CYP3A4 inhibition reduces etonogestrel clearance.
What to do
Monitor for progestin adverse effects such as bleeding irregularities, mood change and fluid retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etonogestrel
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Etonogestrel with Levoketoconazole?
MediHelp rates the interaction as moderate. Etonogestrel and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and can raise etonogestrel exposure, increasing progestogenic effects. Contraceptive efficacy is not expected to be reduced.
How serious is the interaction between Etonogestrel and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestin adverse effects such as bleeding irregularities, mood change and fluid retention.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
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