Drug interactions
Etonogestrel + Omaveloxolone
Severity: Moderate
Etonogestrel and Omaveloxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone is a weak CYP3A4 inducer and may reduce etonogestrel exposure, potentially decreasing contraceptive efficacy.
What this interaction means in plain words
Etonogestrel and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etonogestrel belongs to Endocrine; Omaveloxolone belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 by omaveloxolone may increase etonogestrel metabolism.
What to do
Add a non-hormonal barrier method during treatment and for a short period afterwards, or choose a non-hormonal contraceptive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etonogestrel
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Etonogestrel with Omaveloxolone?
MediHelp rates the interaction as moderate. Etonogestrel and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omaveloxolone is a weak CYP3A4 inducer and may reduce etonogestrel exposure, potentially decreasing contraceptive efficacy.
How serious is the interaction between Etonogestrel and Omaveloxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Add a non-hormonal barrier method during treatment and for a short period afterwards, or choose a non-hormonal contraceptive.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
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