Drug interactions
Etravirine + Ixazomib
Severity: Moderate
Etravirine and Ixazomib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer, though weaker than the strong inducers studied with ixazomib. It could lower ixazomib exposure and reduce efficacy.
What this interaction means in plain words
Etravirine and Ixazomib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Ixazomib belongs to Oncology.
Why it happens
Etravirine induces CYP3A4, increasing ixazomib clearance.
What to do
Monitor myeloma response and consider an alternative antiretroviral if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Ixazomib?
MediHelp rates the interaction as moderate. Etravirine and Ixazomib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer, though weaker than the strong inducers studied with ixazomib. It could lower ixazomib exposure and reduce efficacy.
How serious is the interaction between Etravirine and Ixazomib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor myeloma response and consider an alternative antiretroviral if efficacy declines.
What other medicines interact with Ixazomib?
MediHelp also lists interactions of Ixazomib with, for example, Apalutamide, Carbamazepine, Dabrafenib. The full list is on the Ixazomib page.
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