Drug interactions
Etravirine + Linagliptin
Severity: Minor
Etravirine and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and may lower linagliptin exposure, potentially reducing glucose-lowering effect. The magnitude is probably modest.
What this interaction means in plain words
Etravirine and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Linagliptin belongs to Endocrine.
Why it happens
Induction of CYP3A4 (and possibly P-gp) by etravirine increases linagliptin clearance.
What to do
Monitor glucose and HbA1c; adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Linagliptin?
MediHelp rates the interaction as minor. Etravirine and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine induces CYP3A4 and may lower linagliptin exposure, potentially reducing glucose-lowering effect. The magnitude is probably modest.
How serious is the interaction between Etravirine and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c; adjust antidiabetic therapy if control worsens.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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