Drug interactions
Etravirine + Loratadine
Severity: Minor
Etravirine and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a modest inducer of CYP3A4 and may lower loratadine concentrations. The antihistaminic effect could be slightly reduced, though this is rarely noticeable.
What this interaction means in plain words
Etravirine and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Loratadine belongs to Respiratory.
Why it happens
Induction of CYP3A4 increases the metabolism of loratadine.
What to do
No adjustment is usually needed; if allergy control is inadequate, consider a different antihistamine such as cetirizine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Loratadine?
MediHelp rates the interaction as minor. Etravirine and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine is a modest inducer of CYP3A4 and may lower loratadine concentrations. The antihistaminic effect could be slightly reduced, though this is rarely noticeable.
How serious is the interaction between Etravirine and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is usually needed; if allergy control is inadequate, consider a different antihistamine such as cetirizine.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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