Drug interactions
Etravirine + Methylprednisolone
Severity: Moderate
Etravirine and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a modest inducer of CYP3A4 and may lower methylprednisolone exposure, reducing anti-inflammatory or immunosuppressive effect. Methylprednisolone may also modestly lower etravirine levels, but the clinical significance of this is uncertain.
What this interaction means in plain words
Etravirine and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Methylprednisolone belongs to Endocrine.
Why it happens
Etravirine induces CYP3A4, increasing the metabolism of methylprednisolone, a CYP3A4 substrate.
What to do
Monitor clinical response to methylprednisolone and increase the dose if the effect is inadequate. Monitor HIV viral load during prolonged high-dose steroid therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Methylprednisolone?
MediHelp rates the interaction as moderate. Etravirine and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a modest inducer of CYP3A4 and may lower methylprednisolone exposure, reducing anti-inflammatory or immunosuppressive effect. Methylprednisolone may also modestly lower etravirine levels, but the clinical significance of this is uncertain.
How serious is the interaction between Etravirine and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to methylprednisolone and increase the dose if the effect is inadequate. Monitor HIV viral load during prolonged high-dose steroid therapy.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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