Drug interactions
Etravirine + Modafinil
Severity: Moderate
Etravirine and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil weakly induces CYP3A4 and inhibits CYP2C19, while etravirine is a CYP3A4/2C19 substrate that also induces CYP3A4 and inhibits CYP2C19. Exposure of either drug could shift modestly, with possible reduced modafinil effect or higher etravirine levels. Clinical consequences are usually small.
What this interaction means in plain words
Etravirine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Modafinil belongs to Central Nervous System.
Why it happens
Mutual modulation of CYP3A4 (induction) and CYP2C19 (inhibition) metabolism.
What to do
Monitor for diminished modafinil response and for etravirine adverse effects such as rash; adjust modafinil dose according to clinical effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Modafinil?
MediHelp rates the interaction as moderate. Etravirine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Modafinil weakly induces CYP3A4 and inhibits CYP2C19, while etravirine is a CYP3A4/2C19 substrate that also induces CYP3A4 and inhibits CYP2C19. Exposure of either drug could shift modestly, with possible reduced modafinil effect or higher etravirine levels. Clinical consequences are usually small.
How serious is the interaction between Etravirine and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diminished modafinil response and for etravirine adverse effects such as rash; adjust modafinil dose according to clinical effect.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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