Drug interactions
Etravirine + Oxycodone
Severity: Moderate
Etravirine and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and can lower oxycodone concentrations, potentially reducing pain relief. Oxycodone levels may rebound if etravirine is stopped.
What this interaction means in plain words
Etravirine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Oxycodone belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4 by etravirine increases oxycodone metabolism.
What to do
Monitor analgesic effect and titrate oxycodone upward if needed. When etravirine is discontinued, reduce oxycodone dose and watch for sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Oxycodone?
MediHelp rates the interaction as moderate. Etravirine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer and can lower oxycodone concentrations, potentially reducing pain relief. Oxycodone levels may rebound if etravirine is stopped.
How serious is the interaction between Etravirine and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic effect and titrate oxycodone upward if needed. When etravirine is discontinued, reduce oxycodone dose and watch for sedation and respiratory depression.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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