Drug interactions
Etravirine + Tramadol
Severity: Minor
Etravirine and Tramadol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a modest inducer of CYP3A4 and may lower tramadol concentrations. This could reduce analgesic effect, although the O-desmethyl active metabolite depends mainly on CYP2D6. The effect is likely small.
What this interaction means in plain words
Etravirine and Tramadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Tramadol belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4 by etravirine increasing tramadol clearance.
What to do
Monitor analgesic response and increase the tramadol dose if pain control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Tramadol?
MediHelp rates the interaction as minor. Etravirine and Tramadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine is a modest inducer of CYP3A4 and may lower tramadol concentrations. This could reduce analgesic effect, although the O-desmethyl active metabolite depends mainly on CYP2D6. The effect is likely small.
How serious is the interaction between Etravirine and Tramadol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and increase the tramadol dose if pain control is inadequate.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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