Drug interactions
Etravirine + Trazodone
Severity: Moderate
Etravirine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a modest CYP3A4 inducer and may lower trazodone concentrations, potentially reducing antidepressant or hypnotic effect. The effect is generally gradual and not dangerous.
What this interaction means in plain words
Etravirine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Trazodone belongs to Central Nervous System.
Why it happens
Etravirine induction of CYP3A4 increases trazodone metabolism.
What to do
Monitor clinical response to trazodone and titrate the dose upward if efficacy is lost. Reassess the dose if etravirine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Trazodone?
MediHelp rates the interaction as moderate. Etravirine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a modest CYP3A4 inducer and may lower trazodone concentrations, potentially reducing antidepressant or hypnotic effect. The effect is generally gradual and not dangerous.
How serious is the interaction between Etravirine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to trazodone and titrate the dose upward if efficacy is lost. Reassess the dose if etravirine is stopped.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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