Drug interactions
Everolimus + Rilonacept
Severity: Moderate
Everolimus and Rilonacept: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilonacept blocks interleukin-1 and everolimus is immunosuppressive, so together they may increase the risk of serious infection. Clinical data on the combination are limited.
What this interaction means in plain words
Everolimus and Rilonacept can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Rilonacept belongs to Miscellaneous.
Why it happens
Additive immunosuppression through mTOR inhibition and interleukin-1 blockade.
What to do
Monitor for signs of infection and withhold either drug if a serious infection develops. Screen for latent infections before combined use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Rilonacept
Frequently asked questions
Can I take Everolimus with Rilonacept?
MediHelp rates the interaction as moderate. Everolimus and Rilonacept can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilonacept blocks interleukin-1 and everolimus is immunosuppressive, so together they may increase the risk of serious infection. Clinical data on the combination are limited.
How serious is the interaction between Everolimus and Rilonacept?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and withhold either drug if a serious infection develops. Screen for latent infections before combined use.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
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