Drug interactions
Everolimus + Ritlecitinib
Severity: Moderate
Everolimus and Ritlecitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritlecitinib may inhibit CYP3A4 and raise everolimus exposure. Higher everolimus levels can increase stomatitis, myelosuppression, infection, hyperglycemia, and metabolic toxicity.
What this interaction means in plain words
Everolimus and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Ritlecitinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of everolimus, a sensitive CYP3A4 substrate, by ritlecitinib.
What to do
Monitor everolimus trough concentrations and for adverse effects, and reduce the everolimus dose if levels or toxicity increase. Also consider additive immunosuppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Everolimus and Ritlecitinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Ritlecitinib
Frequently asked questions
Can I take Everolimus with Ritlecitinib?
MediHelp rates the interaction as moderate. Everolimus and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritlecitinib may inhibit CYP3A4 and raise everolimus exposure. Higher everolimus levels can increase stomatitis, myelosuppression, infection, hyperglycemia, and metabolic toxicity.
How serious is the interaction between Everolimus and Ritlecitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough concentrations and for adverse effects, and reduce the everolimus dose if levels or toxicity increase. Also consider additive immunosuppression.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
