Drug interactions
Everolimus + Tacrolimus
Severity: Moderate
Everolimus and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus can potentiate calcineurin inhibitor nephrotoxicity, so full-dose tacrolimus with everolimus can impair renal function. In transplant regimens, tacrolimus exposure must be deliberately lowered when everolimus is added.
What this interaction means in plain words
Everolimus and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity, with mTOR inhibition enhancing calcineurin inhibitor renal toxicity.
What to do
Use the labeled reduced tacrolimus target concentrations when combined with everolimus and monitor tacrolimus and everolimus troughs. Follow serum creatinine and proteinuria regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Everolimus with Tacrolimus?
MediHelp rates the interaction as moderate. Everolimus and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Everolimus can potentiate calcineurin inhibitor nephrotoxicity, so full-dose tacrolimus with everolimus can impair renal function. In transplant regimens, tacrolimus exposure must be deliberately lowered when everolimus is added.
How serious is the interaction between Everolimus and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the labeled reduced tacrolimus target concentrations when combined with everolimus and monitor tacrolimus and everolimus troughs. Follow serum creatinine and proteinuria regularly.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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