Drug interactions
Everolimus + Talquetamab
Severity: Moderate
Everolimus and Talquetamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talquetamab causes cytokine release syndrome, and elevated cytokines can temporarily suppress CYP450 enzymes. This may raise everolimus concentrations and the risk of toxicities such as stomatitis, infection and pneumonitis.
What this interaction means in plain words
Everolimus and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Talquetamab belongs to Oncology.
Why it happens
Cytokine-mediated downregulation of CYP3A4 activity during cytokine release syndrome reduces everolimus metabolism.
What to do
Monitor for everolimus toxicity during talquetamab step-up dosing and for about two weeks after the first treatment dose, and during any CRS. Check everolimus trough levels and reduce the dose if concentrations are high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Everolimus with Talquetamab?
MediHelp rates the interaction as moderate. Everolimus and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talquetamab causes cytokine release syndrome, and elevated cytokines can temporarily suppress CYP450 enzymes. This may raise everolimus concentrations and the risk of toxicities such as stomatitis, infection and pneumonitis.
How serious is the interaction between Everolimus and Talquetamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for everolimus toxicity during talquetamab step-up dosing and for about two weeks after the first treatment dose, and during any CRS. Check everolimus trough levels and reduce the dose if concentrations are high.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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