Drug interactions
Everolimus + Tipranavir
Severity: Major
Everolimus and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, strongly inhibits CYP3A4 and affects P-glycoprotein, which can markedly raise everolimus blood concentrations. Higher exposure increases the risk of mTOR-related toxicity such as infection, mucositis, hyperglycemia, hyperlipidemia and pneumonitis.
What this interaction means in plain words
Everolimus and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Everolimus belongs to Oncology; Tipranavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 and P-gp by ritonavir-boosted tipranavir reduces everolimus metabolism and efflux.
What to do
Avoid the combination where possible and choose an antiretroviral without strong CYP3A inhibition. If unavoidable, reduce the everolimus dose per labeling and monitor everolimus trough levels and toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Everolimus with Tipranavir?
MediHelp rates the interaction as major. Everolimus and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir, given with ritonavir, strongly inhibits CYP3A4 and affects P-glycoprotein, which can markedly raise everolimus blood concentrations. Higher exposure increases the risk of mTOR-related toxicity such as infection, mucositis, hyperglycemia, hyperlipidemia and pneumonitis.
How serious is the interaction between Everolimus and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an antiretroviral without strong CYP3A inhibition. If unavoidable, reduce the everolimus dose per labeling and monitor everolimus trough levels and toxicity.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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