Drug interactions
Everolimus + Trastuzumab deruxtecan
Severity: Moderate
Everolimus and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause myelosuppression and immune suppression, and each is associated with interstitial lung disease or pneumonitis. Combined use may increase the risk of neutropenia, infection and pulmonary toxicity.
What this interaction means in plain words
Everolimus and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive pharmacodynamic myelosuppressive, immunosuppressive and pulmonary toxic effects.
What to do
Monitor blood counts and watch for infection and new respiratory symptoms. Investigate and interrupt therapy promptly if pneumonitis is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Everolimus with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Everolimus and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause myelosuppression and immune suppression, and each is associated with interstitial lung disease or pneumonitis. Combined use may increase the risk of neutropenia, infection and pulmonary toxicity.
How serious is the interaction between Everolimus and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for infection and new respiratory symptoms. Investigate and interrupt therapy promptly if pneumonitis is suspected.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
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