Drug interactions
Everolimus + Trofinetide
Severity: Minor
Everolimus and Trofinetide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide is a weak CYP3A4 inhibitor and may slightly increase everolimus exposure. The clinical effect is likely small but could increase everolimus adverse effects.
What this interaction means in plain words
Everolimus and Trofinetide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Everolimus belongs to Oncology; Trofinetide belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 reduces everolimus metabolism.
What to do
Monitor everolimus trough levels and for adverse effects such as stomatitis and hyperlipidemia. Reduce the everolimus dose if concentrations rise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Trofinetide
Frequently asked questions
Can I take Everolimus with Trofinetide?
MediHelp rates the interaction as minor. Everolimus and Trofinetide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trofinetide is a weak CYP3A4 inhibitor and may slightly increase everolimus exposure. The clinical effect is likely small but could increase everolimus adverse effects.
How serious is the interaction between Everolimus and Trofinetide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough levels and for adverse effects such as stomatitis and hyperlipidemia. Reduce the everolimus dose if concentrations rise.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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