Drug interactions
Everolimus + Vemurafenib
Severity: Moderate
Everolimus and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib inhibits P-glycoprotein and may increase everolimus exposure, while it also induces CYP3A4 to some degree, so the net effect is uncertain. Elevated everolimus levels could increase adverse effects.
What this interaction means in plain words
Everolimus and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Vemurafenib belongs to Oncology.
Why it happens
Vemurafenib inhibits P-glycoprotein efflux of everolimus, with possible opposing weak CYP3A4 induction.
What to do
Monitor everolimus trough concentrations and for toxicity when starting or stopping vemurafenib. Adjust the everolimus dose according to levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Everolimus with Vemurafenib?
MediHelp rates the interaction as moderate. Everolimus and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib inhibits P-glycoprotein and may increase everolimus exposure, while it also induces CYP3A4 to some degree, so the net effect is uncertain. Elevated everolimus levels could increase adverse effects.
How serious is the interaction between Everolimus and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough concentrations and for toxicity when starting or stopping vemurafenib. Adjust the everolimus dose according to levels.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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