Drug interactions
Famotidine + Posaconazole
Severity: Moderate
Famotidine and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole oral suspension needs an acidic stomach for adequate absorption, and acid suppression with H2 blockers can lower its levels. This may risk antifungal treatment or prophylaxis failure. The delayed-release tablets are much less affected.
What this interaction means in plain words
Famotidine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Famotidine belongs to Gastrointestinal Tract; Posaconazole belongs to Anti Fungals.
Why it happens
Increased gastric pH reduces dissolution and absorption of posaconazole suspension.
What to do
Prefer the delayed-release tablet or IV formulation, or take the suspension with a fatty meal. Consider posaconazole level monitoring if the suspension must be used with famotidine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Famotidine
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Famotidine with Posaconazole?
MediHelp rates the interaction as moderate. Famotidine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole oral suspension needs an acidic stomach for adequate absorption, and acid suppression with H2 blockers can lower its levels. This may risk antifungal treatment or prophylaxis failure. The delayed-release tablets are much less affected.
How serious is the interaction between Famotidine and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer the delayed-release tablet or IV formulation, or take the suspension with a fatty meal. Consider posaconazole level monitoring if the suspension must be used with famotidine.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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