Drug interactions
Fedratinib + Fluconazole
Severity: Major
Fedratinib and Fluconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is metabolized by CYP3A4 and CYP2C19, and fluconazole inhibits both. Exposure to fedratinib may rise, increasing risks such as gastrointestinal toxicity, anemia and encephalopathy including Wernicke's.
What this interaction means in plain words
Fedratinib and Fluconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fedratinib belongs to Oncology; Fluconazole belongs to Anti Fungals.
Why it happens
Dual inhibition of CYP3A4 and CYP2C19 by fluconazole reduces fedratinib metabolism.
What to do
Avoid the combination; use an antifungal without dual inhibition. If unavoidable, monitor for toxicity and consider fedratinib dose reduction, and check thiamine status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Fluconazole?
MediHelp rates the interaction as major. Fedratinib and Fluconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fedratinib is metabolized by CYP3A4 and CYP2C19, and fluconazole inhibits both. Exposure to fedratinib may rise, increasing risks such as gastrointestinal toxicity, anemia and encephalopathy including Wernicke's.
How serious is the interaction between Fedratinib and Fluconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an antifungal without dual inhibition. If unavoidable, monitor for toxicity and consider fedratinib dose reduction, and check thiamine status.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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