Drug interactions
Fedratinib + Fluphenazine
Severity: Moderate
Fedratinib and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP2D6, an enzyme that contributes to fluphenazine metabolism, so fluphenazine exposure may rise. This can increase extrapyramidal effects, sedation, hypotension and QT effects.
What this interaction means in plain words
Fedratinib and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Fluphenazine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated metabolism of fluphenazine by fedratinib.
What to do
Monitor for extrapyramidal symptoms, sedation and hypotension, and reduce the fluphenazine dose if adverse effects emerge. Consider an ECG if other QT risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Fluphenazine?
MediHelp rates the interaction as moderate. Fedratinib and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP2D6, an enzyme that contributes to fluphenazine metabolism, so fluphenazine exposure may rise. This can increase extrapyramidal effects, sedation, hypotension and QT effects.
How serious is the interaction between Fedratinib and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and hypotension, and reduce the fluphenazine dose if adverse effects emerge. Consider an ECG if other QT risk factors exist.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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