Drug interactions
Fedratinib + Fluvoxamine
Severity: Major
Fedratinib and Fluvoxamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is metabolized by CYP3A4 and CYP2C19, and fluvoxamine inhibits both, which may increase fedratinib exposure. This raises the risk of GI toxicity, anemia and encephalopathy.
What this interaction means in plain words
Fedratinib and Fluvoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fedratinib belongs to Oncology; Fluvoxamine belongs to Central Nervous System.
Why it happens
Dual CYP3A4 and CYP2C19 inhibition reduces fedratinib clearance.
What to do
Avoid the combination or reduce fedratinib dose per labeling. Monitor for toxicity and neurological symptoms including Wernicke encephalopathy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Fluvoxamine?
MediHelp rates the interaction as major. Fedratinib and Fluvoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fedratinib is metabolized by CYP3A4 and CYP2C19, and fluvoxamine inhibits both, which may increase fedratinib exposure. This raises the risk of GI toxicity, anemia and encephalopathy.
How serious is the interaction between Fedratinib and Fluvoxamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination or reduce fedratinib dose per labeling. Monitor for toxicity and neurological symptoms including Wernicke encephalopathy.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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