Drug interactions
Fedratinib + Haloperidol
Severity: Moderate
Fedratinib and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and CYP2D6, both involved in haloperidol metabolism, and may raise haloperidol concentrations. Higher exposure increases risk of QT prolongation, sedation and extrapyramidal symptoms.
What this interaction means in plain words
Fedratinib and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Haloperidol belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 and CYP2D6 by fedratinib decreases haloperidol clearance.
What to do
Monitor for haloperidol adverse effects and consider an ECG and dose reduction as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Haloperidol?
MediHelp rates the interaction as moderate. Fedratinib and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 and CYP2D6, both involved in haloperidol metabolism, and may raise haloperidol concentrations. Higher exposure increases risk of QT prolongation, sedation and extrapyramidal symptoms.
How serious is the interaction between Fedratinib and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for haloperidol adverse effects and consider an ECG and dose reduction as needed.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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