Drug interactions
Fedratinib + Losartan
Severity: Minor
Fedratinib and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is metabolized by CYP3A4 and CYP2C19, and the concern applies to dual inhibitors. Losartan is not a dual strong inhibitor, so no meaningful rise in fedratinib exposure is expected.
What this interaction means in plain words
Fedratinib and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fedratinib belongs to Oncology; Losartan belongs to Cardiovascular.
Why it happens
No established mechanism; losartan lacks meaningful CYP3A4 or CYP2C19 inhibition.
What to do
No dose change required; monitor for fedratinib toxicity such as GI effects and cytopenias per routine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Losartan?
MediHelp rates the interaction as minor. Fedratinib and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fedratinib is metabolized by CYP3A4 and CYP2C19, and the concern applies to dual inhibitors. Losartan is not a dual strong inhibitor, so no meaningful rise in fedratinib exposure is expected.
How serious is the interaction between Fedratinib and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change required; monitor for fedratinib toxicity such as GI effects and cytopenias per routine care.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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