Drug interactions
Fedratinib + Lurasidone
Severity: Major
Fedratinib and Lurasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor, and lurasidone is a sensitive CYP3A4 substrate. Concurrent use may raise lurasidone concentrations and increase adverse effects such as akathisia, sedation and parkinsonism.
What this interaction means in plain words
Fedratinib and Lurasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fedratinib belongs to Oncology; Lurasidone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated lurasidone metabolism by fedratinib.
What to do
Lurasidone labeling advises reducing the dose when it is combined with moderate CYP3A4 inhibitors, with a lower starting and maximum dose. Monitor for adverse effects and titrate to response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Lurasidone?
MediHelp rates the interaction as major. Fedratinib and Lurasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fedratinib is a moderate CYP3A4 inhibitor, and lurasidone is a sensitive CYP3A4 substrate. Concurrent use may raise lurasidone concentrations and increase adverse effects such as akathisia, sedation and parkinsonism.
How serious is the interaction between Fedratinib and Lurasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Lurasidone labeling advises reducing the dose when it is combined with moderate CYP3A4 inhibitors, with a lower starting and maximum dose. Monitor for adverse effects and titrate to response.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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