Drug interactions
Fedratinib + Norethisterone
Severity: Minor
Fedratinib and Norethisterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may raise norethisterone exposure. Progestogen-related adverse effects could become more pronounced, though the effect is generally modest.
What this interaction means in plain words
Fedratinib and Norethisterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fedratinib belongs to Oncology; Norethisterone belongs to Endocrine.
Why it happens
Fedratinib inhibits CYP3A4, reducing the metabolic clearance of norethisterone.
What to do
No dose change is usually required; monitor for progestogenic adverse effects such as breakthrough bleeding, fluid retention or mood change and review the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Norethisterone?
MediHelp rates the interaction as minor. Fedratinib and Norethisterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fedratinib is a moderate CYP3A4 inhibitor and may raise norethisterone exposure. Progestogen-related adverse effects could become more pronounced, though the effect is generally modest.
How serious is the interaction between Fedratinib and Norethisterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; monitor for progestogenic adverse effects such as breakthrough bleeding, fluid retention or mood change and review the dose if they occur.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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