Drug interactions
Fedratinib + Perphenazine
Severity: Moderate
Fedratinib and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP2D6 and can increase perphenazine exposure, raising the risk of sedation, extrapyramidal effects and QT prolongation.
What this interaction means in plain words
Fedratinib and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Perphenazine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by fedratinib reduces perphenazine metabolism.
What to do
Monitor for perphenazine adverse effects and reduce the dose if they occur. Check ECG in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Perphenazine?
MediHelp rates the interaction as moderate. Fedratinib and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP2D6 and can increase perphenazine exposure, raising the risk of sedation, extrapyramidal effects and QT prolongation.
How serious is the interaction between Fedratinib and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for perphenazine adverse effects and reduce the dose if they occur. Check ECG in patients with QT risk factors.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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