Drug interactions
Fedratinib + Ribociclib
Severity: Major
Fedratinib and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and also a CYP3A4 substrate, so both drugs may raise each other's exposure. This may increase ribociclib QT prolongation and neutropenia and fedratinib toxicities such as GI effects and encephalopathy.
What this interaction means in plain words
Fedratinib and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fedratinib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Mutual CYP3A4 inhibition increases exposure of both drugs.
What to do
Consider reducing ribociclib dose and monitor ECG, electrolytes and blood counts. Watch for fedratinib toxicity including neurologic symptoms and thiamine deficiency.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Ribociclib?
MediHelp rates the interaction as major. Fedratinib and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fedratinib is a moderate CYP3A4 inhibitor and also a CYP3A4 substrate, so both drugs may raise each other's exposure. This may increase ribociclib QT prolongation and neutropenia and fedratinib toxicities such as GI effects and encephalopathy.
How serious is the interaction between Fedratinib and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing ribociclib dose and monitor ECG, electrolytes and blood counts. Watch for fedratinib toxicity including neurologic symptoms and thiamine deficiency.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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