Drug interactions
Fedratinib + Rimegepant
Severity: Moderate
Fedratinib and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and can increase rimegepant exposure. Higher levels may increase the risk of adverse effects.
What this interaction means in plain words
Fedratinib and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Rimegepant belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 metabolism of rimegepant by fedratinib.
What to do
For acute migraine treatment, avoid giving a second rimegepant dose within 48 hours. No adjustment is required for preventive every-other-day dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Rimegepant?
MediHelp rates the interaction as moderate. Fedratinib and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and can increase rimegepant exposure. Higher levels may increase the risk of adverse effects.
How serious is the interaction between Fedratinib and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For acute migraine treatment, avoid giving a second rimegepant dose within 48 hours. No adjustment is required for preventive every-other-day dosing.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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