Drug interactions
Fedratinib + Saxagliptin
Severity: Moderate
Fedratinib and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may increase saxagliptin and active metabolite exposure. The effect is likely modest given saxagliptin's tolerability.
What this interaction means in plain words
Fedratinib and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Saxagliptin belongs to Endocrine.
Why it happens
Fedratinib inhibits CYP3A4, reducing saxagliptin metabolism.
What to do
Monitor for saxagliptin adverse effects and glycemic response; limit saxagliptin to 2.5 mg daily only if a strong CYP3A4 effect is evident.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Saxagliptin?
MediHelp rates the interaction as moderate. Fedratinib and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may increase saxagliptin and active metabolite exposure. The effect is likely modest given saxagliptin's tolerability.
How serious is the interaction between Fedratinib and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for saxagliptin adverse effects and glycemic response; limit saxagliptin to 2.5 mg daily only if a strong CYP3A4 effect is evident.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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