Drug interactions
Felbamate + Flurbiprofen
Severity: Minor
Felbamate and Flurbiprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate may inhibit CYP2C9 and increase flurbiprofen exposure. This could raise the risk of NSAID-related adverse effects.
What this interaction means in plain words
Felbamate and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felbamate belongs to Central Nervous System; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Felbamate inhibition of CYP2C9 may decrease flurbiprofen metabolism.
What to do
Monitor for GI and renal adverse effects and keep the flurbiprofen dose as low as effective.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Flurbiprofen?
MediHelp rates the interaction as minor. Felbamate and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felbamate may inhibit CYP2C9 and increase flurbiprofen exposure. This could raise the risk of NSAID-related adverse effects.
How serious is the interaction between Felbamate and Flurbiprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI and renal adverse effects and keep the flurbiprofen dose as low as effective.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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