Drug interactions
Felbamate + Imipramine
Severity: Moderate
Felbamate and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate inhibits CYP2C19, which participates in imipramine N-demethylation, and may raise imipramine concentrations. Increased exposure can cause more anticholinergic effects, sedation and cardiac toxicity. Both drugs can also lower seizure threshold or affect seizure control.
What this interaction means in plain words
Felbamate and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felbamate belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Felbamate inhibits CYP2C19-mediated metabolism of imipramine.
What to do
Monitor for signs of tricyclic toxicity and consider checking plasma levels. Lower the imipramine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Imipramine?
MediHelp rates the interaction as moderate. Felbamate and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felbamate inhibits CYP2C19, which participates in imipramine N-demethylation, and may raise imipramine concentrations. Increased exposure can cause more anticholinergic effects, sedation and cardiac toxicity. Both drugs can also lower seizure threshold or affect seizure control.
How serious is the interaction between Felbamate and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of tricyclic toxicity and consider checking plasma levels. Lower the imipramine dose if adverse effects occur.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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