Drug interactions
Felbamate + Meloxicam
Severity: Minor
Felbamate and Meloxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate inhibits CYP2C19 and has some effect on other CYP enzymes, but a clinically meaningful effect on CYP2C9-mediated meloxicam metabolism is not well documented. Any increase in meloxicam exposure would be expected to be small.
What this interaction means in plain words
Felbamate and Meloxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felbamate belongs to Central Nervous System; Meloxicam belongs to Musculoskeletal.
Why it happens
Possible weak inhibition of CYP2C9 metabolism of meloxicam; not firmly established.
What to do
No routine adjustment is needed; monitor for NSAID adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Meloxicam?
MediHelp rates the interaction as minor. Felbamate and Meloxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felbamate inhibits CYP2C19 and has some effect on other CYP enzymes, but a clinically meaningful effect on CYP2C9-mediated meloxicam metabolism is not well documented. Any increase in meloxicam exposure would be expected to be small.
How serious is the interaction between Felbamate and Meloxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for NSAID adverse effects.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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