Drug interactions
Felbamate + Nateglinide
Severity: Minor
Felbamate and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate inhibits CYP2C19 and can affect other CYP enzymes, but it has no well-established effect on CYP2C9 substrates like nateglinide. Any rise in nateglinide levels is theoretical.
What this interaction means in plain words
Felbamate and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felbamate belongs to Central Nervous System; Nateglinide belongs to Endocrine.
Why it happens
Possible weak inhibition of CYP2C9-mediated nateglinide metabolism; not well established.
What to do
No routine adjustment is needed. Monitor blood glucose when felbamate is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Nateglinide?
MediHelp rates the interaction as minor. Felbamate and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felbamate inhibits CYP2C19 and can affect other CYP enzymes, but it has no well-established effect on CYP2C9 substrates like nateglinide. Any rise in nateglinide levels is theoretical.
How serious is the interaction between Felbamate and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor blood glucose when felbamate is started or stopped.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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