Drug interactions
Felodipine + Tucatinib
Severity: Moderate
Felodipine and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and may raise felodipine exposure, causing hypotension and edema. Felodipine is not a clinically important CYP2C8 inhibitor, so the reverse effect is unlikely to matter.
What this interaction means in plain words
Felodipine and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, decreasing felodipine metabolism.
What to do
Monitor blood pressure and heart rate and reduce the felodipine dose if hypotension or marked edema develops. Consider an alternative antihypertensive if the effect is not manageable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Felodipine with Tucatinib?
MediHelp rates the interaction as moderate. Felodipine and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and may raise felodipine exposure, causing hypotension and edema. Felodipine is not a clinically important CYP2C8 inhibitor, so the reverse effect is unlikely to matter.
How serious is the interaction between Felodipine and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and reduce the felodipine dose if hypotension or marked edema develops. Consider an alternative antihypertensive if the effect is not manageable.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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